Endocrine Abstracts

Purpose: The aim of the study was to evaluate the relationships of apelin with the parameters of the carbohydrate metabolism in hypertensive patients with type 2 diabetes (T2D) and without T2D.Methods: The study involved 93 patients with hypertension grades 2–3 combined with T2D or without it (45 men and 48 women) in age from 43 to 70 years old. The investigation complex included measuring levels of fasting blood glucose, fasting blood insulin with ...

Introduction: Apelin is one of the cardiovascular factors, adipokin, which plays an important role not only in the pathogenesis of hypertension, but also of type 2 diabetes (T2D). The aim of the study was to assess apelin levels in blood serum and investigate its relationship with duration of diabetes in hypertension patients with T2D.Methods: The study involved 63 hypertension patients grades 2–3 with T2D (32 men and 31 women) aged 43 to 70. Depend...

Gut microbiota, its phylotypes, the Firmicutes/Bacteroidetes ratio can play important role in the pathogenesis of arterial hypertension, obesity and metabolic disorders. The aim of the study was to evaluate the content of the main phylotypes of the gut microbiota (Firmicutes, Bacteroidetes and Actinobacteria), the Firmicutes/Bacteroidetes ratio in patients with arterial hypertension, abdominal obesity and pre-diabetes.Materials and...

Introduction: Endogenous peptide apelin has profound hypotensive and inotropic effects, improves glucose utilization, which emphasizes its importance in the pathogenesis as essential hypertension (EH) and type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the blood levels of apelin in patients with EH in combination with T2DM.Description of methods/design: The examination involved 19 patients with EH grades 2–3 with T2DM (eigh...

The combination of hypertension and type 2 diabetes mellitus (T2DM) greatly increases the risk of adverse cardiovascular events. Identification of factors which accelerate the development of atherosclerosis, it is important to more fully understand the mechanisms of progression of these diseases.The aim is to study the relationship between levels of transforming growth factor-β1 (TGF-β1), insulin-like growth factor-1 (IGF-1) and lipid peroxidat...